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KMID : 0374019920150030175
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Ewha Medical Journal
1992 Volume.15 No. 3 p.175 ~ p.184
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An Experimental Study of the Effect of Radiation and Cis-Dichlorodiammineplatinum(Ⅱ) on the Rectum of Rat
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Abstract
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The effects of radiation and Cis-dichlorodiammineplatinum(II)(Cis DDP) were assessed in rectum of rats by histopathological changes. Rats were exposed to single doses of X ray(6~10Gy) without or with Cis DDP(2.5mg/kg). In combined group. Cis DDP
was
given 30 minntes before or immediately after irradiation. Cis DDP alone showed inflammatory. Cell infiltration and increased goblet cells in the mucosa and edema and fibrosis of submucosa with vascular sclerosis. With increased radiation dosage.
Such
changes were aggravated. Necrosis of muscle layer was developed 8 Gy irradiation. In groups with combination treatment of X ray and Cis-DDP. Changes of mucosa and submucosa were not significantly different from radiation alone group, but necrosis
of the
muscle layer was developed in 6 Gy combination group and degree was more severe in 8 and 10 Gy combination group compared to radiation alone group. There was no difference according to the timing of Cis-DDP administration before or after
irradiation.
This results suggest Cis-DDP enhance the radiation effect on the rectum of rats and enhancement ratio was 1.3 as the endpoint was necrosis of the muscle layer.
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KEYWORD
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